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Mental Health Trials

Welcome to the Mental Health Trials search page.

Here we aim to provide a centralised location for the public, including people with lived experience in mental health and their carers, researchers, clinicians, and other stakeholders to access information about planned, recruiting, and completed mental health clinical trials.

We welcome applications for all Mental Health Trials! If you would like your trial listed on the MAGNET website, please email: magnet@deakin.edu.au

Mental Health Trials Application Form

 

  • Search Mental Health Trials by short name, study title, ANCTR and MAGNET number

  • Recruiting locations

  • Topics

  • Trial Stage

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TRI-ME

CURRENTLY RECRUITING
TRI-ME: Trimetazidine to treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A double-blind, randomised, placebo-controlled efficacy trial

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness accompanied by a series of debilitating and persistent symptoms. Extensive research nominated a safe cardiac medication to be repurposed to potentially treat ME/CFS. TRI-ME will test whether this novel treatment can help tackle major symptoms of ME/CFS.
Recruiting locations: VIC
Topics: Myalgic Encephalomyelitis, Chronic Fatigue Syndrome Trial Type: Investigator led trial
ACTN Number: ACTRN12625000095460 Email: tri-me@deakin.edu.au

Efficacy of scalable approaches to reducing alcohol and other drug use among traumatised young people

CURRENTLY RECRUITING
A randomised, parallel-group, non-inferiority trial to compare the efficacy of an integrated cognitive-behavioural therapy (COPE-A) for substance use and traumatic stress among adolescents and young adults delivered via telehealth versus in person.

This trial is investigating approaches to the treatment of post traumatic stress disorder and substance use disorder among adolescents and young people aged 12-25 years. Paticipants will be randomised to receive up to 16 sessions of an integrated cognitive behavioural therapy (COPE-A) with a registered psychologist, delivered either in person or via telehealth.
Recruiting locations: NSW
Topics: Post Traumatic Stress Disorder Trial Type: Investigator led trial
ANZCTR Registration Number: ACTRN12624000776505 Email: matilda.copea@sydney.edu.au

The Evolve Study

CURRENTLY RECRUITING
Evaluating the Impact of a Digital Youth Mental Health Service: A pragmatic randomised controlled trial of a digital mental health service for youth with anxiety and depression

The study has two primary aims: To test the effectiveness of Moderated Online Social Therapy (MOST) by comparing the effectiveness and cost-effectiveness against treatment-as-usual for young people in the community and, for those who receive MOST, to determine what combination of interventions work most effectively to reduce transdiagnostic symptoms.
Recruiting locations: NSW, NT, SA, TAS, VIC
Topics: Youth Mental Health, Anxiety, Depression Trial Type: Investigator led trial
ANZCTR Registration Number: ACTRN12624000857505 Email: evolve-study@unimelb.edu.au

The Affinity Study

CURRENTLY RECRUITING
Evaluating the Impact of a Digital Youth Mental Health Service: A pragmatic trial of a targeted digital intervention for youth with suicidal thoughts and behaviours

The Affinity trial aims to assess the efficacy of novel intervention content delivered on the moderated online social therapy (MOST) in reducing suicidal thoughts and behaviours in young people attending outpatient or community care. The intervention content has been developed based on the interpersonal theory of suicide.
Recruiting locations: NSW, NT, SA, TAS, VIC
Topics: Suicidal Ideation, Youth Mental Health, Digital Mental Health Interventions Trial Type: Investigator led trial
ANZCTR Registration Number: ACTRN12623001059651 Email: affinity@orygen.org.au

OPTIMISM

CURRENTLY RECRUITING
OPTIMISM: A Proof-of-Concept Trial

OPTIMISM is a 4-week double-blind placebo-controlled feeding trial in 44 adults with major depression. The study aims to investigate the effect of two dietary patterns on depressive symptoms, other psychological endpoints and various biological endpoints to understand potential mechanisms. All meals and snacks will be provided to participants for the duration of the study.
Recruiting locations: VIC
Topics: Major Depression Trial Type: Investigator led trial
ANZCTR Registration Number: 12623001162606 Email: optimismscreen@monash.edu

CADET-UD

CURRENTLY RECRUITING
The Candesartan Adjunctive Major Depression Trial – CADET: A double-blind, randomised, placebo-controlled trial

New research suggests a commonly prescribed and well tolerated blood pressure medication may have anti-depressant properties. This Deakin University led trial aims to assess if this medication may help to reduce symptoms of depression in major depressive disorder and improve general quality of life, in addition to usual treatment.
Recruiting locations: QLD, VIC
Topics: Major Depression Trial Type: Investigator led trial
ANZCTR Number: ACTRN12620001095954 Email: Cadet-trial@deakin.edu.au

CADET-BD

CURRENTLY RECRUITING
The Candesartan Adjunctive Bipolar Depression Trial – CADET: A double-blind, randomised, placebo-controlled trial

New research suggests a commonly prescribed and well tolerated blood pressure medication may have anti-depressant properties. This Deakin University led trial aims to assess if this medication may help to reduce symptoms of depression in bipolar disorder and improve general quality of life, in addition to usual treatment.

 
Recruiting locations: QLD, VIC
Topics: Bipolar Disorder, Depression Trial Type: Investigator led trial
ANZCTR Registration Number: ACTRN12620000703909 Email: Cadet-trial@deakin.edu.au

The STOP Trial

CURRENTLY RECRUITING
Silexan in the Treatment Of Posttraumatic stress disorder (STOP) trial

The STOP Trial is investigating whether lavender oil is an effective treatment for PTSD. Participants will take lavender oil or placebo capsules daily for 12 weeks in addition to their usual medications. They will complete questionnaires every 2-4 weeks until week 16 (i.e. 4 weeks post-treatment).
Recruiting locations: * Online (Australia wide), ACT, NSW, NT, QLD, SA, TAS, VIC
Topics: Post Traumatic Stress Disorder Trial Type: Investigator led trial
ClinicalTrials.gov Number: NCT06412757 MAGNET Number: TEA_014 Email: stop-trial@unimelb.edu.au

Hearts & Minds

SET UP STAGE CURRENTLY RECRUITING
Metformin and Atorvastatin in Major Depression: The Hearts and Minds Double-Blind, Randomised, Placebo-Controlled Trial

The research project aims to test if two medications – atorvastatin or metformin – may help to reduce symptoms of major depression and improve quality of life. Atorvastatin is a medication to treat high cholesterol and metformin XR is a medication to treat diabetes.  There is evidence that both medications might also reduce depression symptoms.
Recruiting locations: SA, TAS, VIC
Topics: Major Depression Trial Type: MAGNET Signature Trial
ANZCTR Number: ACTRN12623000611628 MAGNET Number: Sig. Trial Email: hm2@deakin.edu.au

Kite

SET UP STAGE CURRENTLY RECRUITING
The Kite Trial: Examining the Effectiveness of Low Dose Ketamine for Depression in Bipolar Disorder

Evidence suggests that low dose ketamine is an effective treatment for unipolar depression. Kite is a randomised controlled trial investigating whether low dose ketamine is an effective treatment for bipolar depression. Participants will be randomised to receive six doses of either ketamine or midazolam (an active control medication).
Recruiting locations: NSW, SA, VIC
Topics: Bipolar Disorder Trial Type: MAGNET Signature Trial
ANZCTR Number: ACTRN12624000789561 MAGNET Number: Sig. Trial Email: kite-enquiries@unimelb.edu.au

HeLiPaD

CURRENTLY RECRUITING
The HeLiPaD Trial: Brief Online Workplace Training Program to Support Help-Seeking for Mental Ill-Health.

The HeLiPaD trial is testing a brief online educational program for supporting mental health in workplaces. The program was co-designed by a stakeholder group. We are recruiting workplaces to participate in a cluster randomised controlled trial to test whether the program improves help seeking and reduces stigma.
Recruiting locations: * Online (Australia wide), ACT, NSW, NT, QLD, SA, TAS, VIC, WA
Topics: Help Seeking, Internet, Mental Health, Workplace Trial Type: MAGNET Signature Trial
ANZCTR Number: ACTRN12623000270617 MAGNET Number: Sig. Trial Email: helipad@anu.edu.au

HARMON-E

CURRENTLY RECRUITING
The HARMON-E Trial: Evaluating the Effectiveness of a Comprehensive Lifestyle Therapy Program Versus Psychological Care for Managing Mood Disorders

The HARMON-E trial is comparing the effects of two different group-based therapies for mental health. Participants with depression or bipolar disorder will be randomly placed into one of two groups to receive sessions from either allied health professionals, or registered psychologists.
Recruiting locations: * Online (Australia wide), ACT, NSW, NT, QLD, SA, TAS, VIC, WA
Topics: Major Depression, Bipolar Disorder, Psychotherapy, Lifestyle Trial Type: MAGNET Signature Trial
ANZCTR Number: ACTRN12622001026718 MAGNET Number: Sig. Trial Email: harmone@deakin.edu.au